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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein of human CBL |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
3.19 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
Gene Aliases: C-CBL; CBL; CBL2; FRA11B; NSLL; RGD1561386; RNF55
UniProt ID: (Human) P22681
Entrez Gene ID: (Human) 867, (Rat) 500985
Molecular Function:
ligase
metabolite interconversion enzyme
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