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OriGene
CBL Polyclonal Antibody
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Product Details
TA890105
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human CBL
Conjugate
Form
Liquid
Concentration
3.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-cbl; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; Casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL-3; CBLC; E3 ubiquitin-protein ligase CBL; fragile site, folic acid type, rare, fra(11)(q23.3); oncogene CBL2; Proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF57; Signal transduction protein CBL
Gene Aliases: C-CBL; CBL; CBL2; FRA11B; NSLL; RGD1561386; RNF55
UniProt ID: (Human) P22681
Entrez Gene ID: (Human) 867, (Rat) 500985
phosphotyrosine binding
ubiquitin-protein transferase activity
calcium ion binding
protein binding
zinc ion binding
transferase activity
SH3 domain binding
protein kinase binding
receptor tyrosine kinase binding
phosphatidylinositol 3-kinase regulatory subunit binding
cadherin binding
metal ion binding
ephrin receptor binding
ubiquitin protein ligase activity
protein tyrosine kinase binding
signal transducer activity
ligase
metabolite interconversion enzyme
protein polyubiquitination
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular response to DNA damage stimulus
signal transduction
cell surface receptor signaling pathway
male gonad development
response to gamma radiation
response to activity
protein ubiquitination
cytokine-mediated signaling pathway
regulation of signaling
regulation of Rap protein signal transduction
response to testosterone
cellular response to platelet-derived growth factor stimulus
negative regulation of epidermal growth factor receptor signaling pathway
response to starvation
negative regulation of apoptotic process
mast cell degranulation
response to ethanol
positive regulation of epidermal growth factor receptor signaling pathway
viral entry into host cell
positive regulation of receptor-mediated endocytosis
protein autoubiquitination
positive regulation of protein kinase B signaling
ubiquitin-dependent endocytosis
cellular response to hypoxia
regulation of intracellular signal transduction
cellular response to nerve growth factor stimulus
regulation of platelet-derived growth factor receptor-alpha signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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