Immunogen sequence: RKHSNLITVP IQDDSNSGAR EPPPPAPAPA HHHPEYQGQP VVSHPHHIMP PQQHYAPPPP PPPPISHPMP
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-Cbl-like protein 1; Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; Cbl proto-oncogene like 1, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase; E-cadherin binding protein E7; E3 ubiquitin-protein ligase Hakai; RING finger protein 188; RING-type E3 ubiquitin transferase Hakai
Gene Aliases: CBLL1; HAKAI; RNF188
UniProt ID: (Human) Q75N03
Entrez Gene ID: (Human) 79872
Molecular Function: ligase