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Invitrogen
CBP Polyclonal Antibody
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Product Details
PA5-32367
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to C-terminus of human CBP
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.6, with 1% BSA
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is tonsil tissue.
Target Information
CBP for CREB-binding protein is a 265 kDa nuclear protein which probably has many of the properties expected of a CREB co-activator. It shows substantial sequence homology with p300.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CBP/p300; CBP; CREBBP; CREB-binding protein; CREBBP; Histone lysine acetyltransferase CREBBP; KAT3A; Protein lactyltransferas CREBBP; Protein-lysine acetyltransferase CREBBP; RSTS; unnamed protein product
Gene Aliases: CBP; CREBBP; KAT3A; MKHK1; RSTS; RSTS1
UniProt ID: (Human) Q92793
Entrez Gene ID: (Human) 1387
transcription coactivator binding
p53 binding
chromatin binding
damaged DNA binding
transcription cofactor activity
transcription coactivator activity
transcription corepressor activity
histone acetyltransferase activity
protein binding
zinc ion binding
acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
chromatin DNA binding
MRF binding
histone acetyltransferase activity (H3-K18 specific)
histone acetyltransferase activity (H3-K27 specific)
metal ion binding
tau protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
peptide-lysine-N-acetyltransferase activity
peptide lactyltransferase (CoA-dependent) activity
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
response to hypoxia
stimulatory C-type lectin receptor signaling pathway
chromatin remodeling
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein acetylation
signal transduction
I-kappaB kinase/NF-kappaB signaling
regulation of smoothened signaling pathway
negative regulation of transcription from RNA polymerase I promoter
N-terminal peptidyl-lysine acetylation
positive regulation of transforming growth factor beta receptor signaling pathway
protein destabilization
cellular response to nutrient levels
cellular response to UV
homeostatic process
embryonic digit morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
protein stabilization
protein-containing complex assembly
protein K48-linked deubiquitination
energy homeostasis
regulation of cellular response to heat
positive regulation of protein localization to nucleus
positive regulation of double-strand break repair via homologous recombination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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