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Invitrogen
CBS Polyclonal Antibody
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Product Details
PA5-22273
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CBS. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.81 mg/mL
Amount
81 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa, 293T, mouse liver.
Predicted reactivity: Mouse (94%), Rat (94%), Xenopus laevis (93%), Rabbit (95%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Beta-thionase; Cystathionine beta-synthase; Cystathionine beta-synthase-like protein; cystathionine-beta-synthase; Hemoprotein H-450; methylcysteine synthase; Serine sulfhydrase; unnamed protein product
Gene Aliases: AI047524; AI303044; CBS; CBSL; HIP4
UniProt ID: (Human) P35520, (Rat) P32232, (Mouse) Q91WT9
Entrez Gene ID: (Human) 875, (Rat) 24250, (Mouse) 12411
catalytic activity
cystathionine beta-synthase activity
protein binding
lyase activity
oxygen binding
enzyme binding
heme binding
pyridoxal phosphate binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding
nitrite reductase (NO-forming) activity
carbon monoxide binding
nitric oxide binding
modified amino acid binding
S-adenosyl-L-methionine binding
lyase
metabolite interconversion enzyme
endochondral ossification
blood vessel remodeling
cysteine metabolic process
cysteine biosynthetic process from serine
L-serine metabolic process
L-serine catabolic process
superoxide metabolic process
cellular amino acid biosynthetic process
serine family amino acid metabolic process
regulation of nitric oxide mediated signal transduction
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
L-cysteine catabolic process
cerebellum morphogenesis
response to nutrient levels
DNA protection
negative regulation of apoptotic process
homocysteine catabolic process
sulfur compound biosynthetic process
regulation of JNK cascade
homocysteine metabolic process
response to folic acid
maternal process involved in female pregnancy
cartilage development involved in endochondral bone morphogenesis
hydrogen sulfide biosynthetic process
cellular response to hypoxia
regulation of blood vessel diameter
regulation of cGMP metabolic process
regulation of JUN kinase activity
regulation of blood vessel size
oxidation-reduction process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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