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Peptide sequence: RCIIVMPEKM SSEKVDVLRA LGAEIVRTPT NARFDSPESH VGVAWRLKNE
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 93%
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-thionase; Cystathionine beta-synthase; Cystathionine beta-synthase-like protein; Cystathionine-beta-synthase; Hemoprotein H-450; HIP4; methylcysteine synthase; Serine sulfhydrase
Gene Aliases: AI047524; AI303044; BOS_1395; CBS; CBSL; HIP4
UniProt ID: (Rabbit) Q9N0V7, (Human) P0DN79, (Rat) P32232, (Mouse) Q91WT9
Entrez Gene ID: (Bovine) 514525, (Dog) 611071, (Rabbit) 100008766, (Human) 875, (Rat) 24250, (Guinea pig) 100734876, (Mouse) 12411
Molecular Function:
deaminase
dehydratase
epimerase/racemase
hydrolase
isomerase
lyase
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