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Invitrogen
CBS Polyclonal Antibody
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Product Details
PA5-42770
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human CBS (aa 164-213).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: RCIIVMPEKM SSEKVDVLRA LGAEIVRTPT NARFDSPESH VGVAWRLKNE
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 93%
Target Information
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-thionase; Cystathionine beta-synthase; cystathionine-beta-synthase; Hemoprotein H-450; methylcysteine synthase; Serine sulfhydrase
Gene Aliases: AI047524; AI303044; CBS; HIP4
UniProt ID: (Human) P35520, (Rat) P32232, (Mouse) Q91WT9
Entrez Gene ID: (Human) 875, (Rat) 24250, (Mouse) 12411
cystathionine beta-synthase activity
cysteine synthase activity
protein binding
oxygen binding
enzyme binding
heme binding
pyridoxal phosphate binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding
nitrite reductase (NO-forming) activity
carbon monoxide binding
nitric oxide binding
modified amino acid binding
S-adenosyl-L-methionine binding
lyase activity
lyase
metabolite interconversion enzyme
cysteine biosynthetic process from serine
L-serine metabolic process
L-serine catabolic process
cellular amino acid biosynthetic process
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
L-cysteine catabolic process
DNA protection
homocysteine catabolic process
homocysteine metabolic process
oxidation-reduction process
hydrogen sulfide biosynthetic process
endochondral ossification
blood vessel remodeling
superoxide metabolic process
cerebellum morphogenesis
regulation of cGMP metabolic process
response to nutrient levels
negative regulation of apoptotic process
regulation of JUN kinase activity
regulation of blood vessel size
response to folic acid
maternal process involved in female pregnancy
cartilage development involved in endochondral bone morphogenesis
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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