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Invitrogen
CBS Polyclonal Antibody
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FIGURE: 1 / 2
CBS Antibody (PA5-94923) in IHC (P)
Immunohistochemical analysis of CBS in a paraffin-embedded section of human liver cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1 μg/mL rabbit anti-CBS antibody (Product # PA5-94923) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as s... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-94923
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human CBS recombinant protein (Position: A331-K551).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL once reconstituted
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Human CBS shares 83% amino acid (aa) sequence identity with both mouse and rat CBS.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human 293T whole cell, human K562 whole cell, rat liver tissue, rat pancrease tissue, mouse liver tissue, mouse pancrease tissue. IHC: human liver cancer tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-thionase; hemoprotein H-450; methylcysteine synthase; serine sulfhydrase; unnamed protein product
Gene Aliases: HIP4
UniProt ID: (Human) P35520, (Mouse) Q91WT9, (Rat) P32232
Entrez Gene ID: (Human) 875, (Mouse) 12411, (Rat) 24250
cystathionine beta-synthase activity
protein binding
oxygen binding
enzyme binding
heme binding
pyridoxal phosphate binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
nitrite reductase (NO-forming) activity
carbon monoxide binding
nitric oxide binding
modified amino acid binding
S-adenosyl-L-methionine binding
selenocystathionine beta-synthase activity
selenium compound metabolic process
endochondral ossification
blood vessel remodeling
L-serine metabolic process
L-serine catabolic process
superoxide metabolic process
cysteine biosynthetic process
transsulfuration
L-cysteine catabolic process
cerebellum morphogenesis
response to nutrient levels
cellular response to insulin stimulus
DNA protection
negative regulation of apoptotic process
homocysteine catabolic process
sulfur compound biosynthetic process
regulation of JNK cascade
homocysteine metabolic process
response to folic acid
maternal process involved in female pregnancy
cartilage development involved in endochondral bone morphogenesis
hydrogen sulfide biosynthetic process
cellular response to hypoxia
regulation of blood vessel diameter
negative regulation of nitric oxide-cGMP mediated signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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