Proteintech

CBX2 Polyclonal Antibody

FIGURE: 1 / 4

CBX2 Antibody (15579-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 15579-1-AP) (CBX2 antibody) at dilution of 1:4,000 incubated at room temperature for 1.5 hours.

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Product Details

15579-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CBX2 Fusion Protein Ag7979 (1-211 aa encoded by BC004252)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEELSSVGE QVFAAECILS KRLRKGKLEY LVKWRGWSSK HNSWEPEENI LDPRLLLAFQ KKEHEKEVQN RKRGKRPRGR PRKLTAMSSC SRRSKLKVGG CAGYADPTSQ HPLGVGGRQR EGLGPSGRGW HFCQQSVPLL GKQEPPFFLS LSFCCQGPQP AESSSPPLPG ASCFSLSCTP LCWVAGSNCC RQALFPPRGS LGDGKEQEAC VQ (1-211 aa encoded by BC004252)

Target Information

MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.

Molecular carcinogenesis

Ma Y,Liu L,Wei Z,Zhu M,Huang L,Wang S,Yi X,Ying F,Zhao S,Cai J,Wang Z,Sun S

Sat Apr 01 00:00:00 EDT 2023

Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.

Molecular carcinogenesis

Ma Y,Liu L,Wei Z,Zhu M,Huang L,Wang S,Yi X,Ying F,Zhao S,Cai J,Wang Z,Sun S

Sat Apr 01 00:00:00 EDT 2023

Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.

Molecular carcinogenesis

Ma Y,Liu L,Wei Z,Zhu M,Huang L,Wang S,Yi X,Ying F,Zhao S,Cai J,Wang Z,Sun S

Sat Apr 01 00:00:00 EDT 2023

SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.

Cell reports

Zhou H,Feng W,Yu J,Shafiq TA,Paulo JA,Zhang J,Luo Z,Gygi SP,Moazed D

Tue Apr 25 00:00:00 EDT 2023

Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis.

Oncology letters

Meng X,Cao R,Liu X,Fu B,Luo L,Jiang M,Wang K,Liu Y,Zhu Q,Yang C,Zhou L

Sat Apr 01 00:00:00 EDT 2023

Overexpression of CBX2 in breast cancer promotes tumor progression through the PI3K/AKT signaling pathway.

American journal of translational research

Zheng S,Lv P,Su J,Miao K,Xu H,Li M

Sat Apr 09 00:00:00 EDT 2022

Overexpression of CBX2 in breast cancer promotes tumor progression through the PI3K/AKT signaling pathway.

American journal of translational research

Zheng S,Lv P,Su J,Miao K,Xu H,Li M

Sat Apr 09 00:00:00 EDT 2022

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 EDT 2018

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: cell division cycle associated 6; chromobox homolog 2; chromobox homolog 2 (Pc class homolog, Drosophila); Chromobox protein homolog 2; hromobox homolog 2; M33; M33 polycomb-like protein; modifier 3; Modifier 3 protein; Pc class homolog; polycomb

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Gene Aliases: CBX2; CDCA6; M33; MOD2; pc; SRXY5

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UniProt ID: (Human) Q14781, (Mouse) P30658

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Entrez Gene ID: (Human) 84733, (Mouse) 12416, (Rat) 303730

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Function(s)

DNA binding chromatin binding protein binding methylated histone binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated chromatin modification development of primary sexual characteristics covalent chromatin modification protein sumoylation cell differentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CBX2 Polyclonal Antibody

CBX2 Antibody (15579-1-AP) in WB

Product Details

15579-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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