|Tested species reactivity||Human, Mouse|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 161 of Human CBX2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA5-30996 targets CBX2 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-30996 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 161 of Human CBX2.
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer.
PA5-30996 was used in western blot to determine a potential drug target in advanced prostate cancer by identifying the epigenetic reader CBX2
|Clermont PL,Crea F,Chiang YT,Lin D,Zhang A,Wang JZ,Parolia A,Wu R,Xue H,Wang Y,Ding J,Thu KL,Lam WL,Shah SP,Collins CC,Wang Y,Helgason CD||Clinical epigenetics (8:null)||2016|