Proteintech

CCAR2 Polyclonal Antibody

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CCAR2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using KIAA1967 antibody 22638-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

CCAR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human pancreas cancer slide using 22638-1-AP (CCAR2 antibody at dilution of 1:50.

CCAR2 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 22638-1-AP (CCAR2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CCAR2 Antibody in Immunoprecipitation (IP) — IP result of anti-CCAR2 (IP:22638-1-AP, 4ug; Detection:22638-1-AP 1:1000) with mouse brain tissue lysate 4000ug.

Product Details

22638-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CCAR2 Fusion Protein Ag18374 (571-923 aa encoded by BC018269)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: EPEKEEAAK EEATKEEEAI KEEVVKEPKD EAQNEGPATE SEAPLKEDGL LPKPLSSGGE EEEKPRGEAS EDLCEMALDP ELLLLRDDGE EEFAGAKLED SEVRSVASNQ SEMEFSSLQD MPKELDPSAV LPLDCLLAFV FFDANWCGYL HRRDLERILL TLGIRLSAEQ AKQLVSRVVT QNICQYRSLQ YSRQEGLDGG LPEEVLFGNL DLLPPPGKST KPGAAPTEHK ALVSHNGSLI NVGSLLQRAE QQDSGRLYLE NKIHTLELKL EESHNRFSAT EVTNKTLAAE MQELRVRLAE AEETARTAER QKSQLQRLLQ ELRRRLTPLQ LEIQRVVEKA DSWVEKEEPA PSN (571-923 aa encoded by BC018269)

Target Information

DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.

eLife

Liu Q,Luo Q,Feng J,Zhao Y,Ma B,Cheng H,Zhao T,Lei H,Mu C,Chen L,Meng Y,Zhang J,Long Y,Su J,Chen G,Li Y,Hu G,Liao X,Chen Q,Zhu Y

Mon Aug 01 00:00:00 EDT 2022

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.

eLife

Liu Q,Luo Q,Feng J,Zhao Y,Ma B,Cheng H,Zhao T,Lei H,Mu C,Chen L,Meng Y,Zhang J,Long Y,Su J,Chen G,Li Y,Hu G,Liao X,Chen Q,Zhu Y

Mon Aug 01 00:00:00 EDT 2022

Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.

eLife

Liu Q,Luo Q,Feng J,Zhao Y,Ma B,Cheng H,Zhao T,Lei H,Mu C,Chen L,Meng Y,Zhang J,Long Y,Su J,Chen G,Li Y,Hu G,Liao X,Chen Q,Zhu Y

Mon Aug 01 00:00:00 EDT 2022

Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Niri F,Terpstra AN,Lim KRQ,McDermid HE

Wed Dec 01 00:00:00 EST 2021

Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Niri F,Terpstra AN,Lim KRQ,McDermid HE

Wed Dec 01 00:00:00 EST 2021

Corrigendum to article "Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation''.

Nucleic acids research

Chen R,Liu Y,Zhuang H,Yang B,Hei K,Xiao M,Hou C,Gao H,Zhang X,Jia C,Li L,Li Y,Zhang N

Mon Apr 19 00:00:00 EDT 2021

Corrigendum to article "Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation''.

Nucleic acids research

Chen R,Liu Y,Zhuang H,Yang B,Hei K,Xiao M,Hou C,Gao H,Zhang X,Jia C,Li L,Li Y,Zhang N

Mon Apr 19 00:00:00 EDT 2021

Bioinformatics

Protein Aliases: Cell cycle and apoptosis regulator protein 2; Cell division cycle and apoptosis regulator protein 2; DBC-1; DBC.1; DBCCR1; DBIRD complex subunit KIAA1967; deleted in breast cancer 1; Deleted in breast cancer gene 1 protein; FAM5A; NET35; p30 DBC; p30 DBC protein

Gene Aliases: 2610301G19Rik; CCAR2; DBC-1; DBC1; KIAA1967; mKIAA1967; NET35; p30 DBC; p30DBC; RGD1309922

UniProt ID: (Human) Q8N163, (Mouse) Q8VDP4

Entrez Gene ID: (Human) 57805, (Mouse) 219158, (Rat) 306007

Molecular Function: chromatin/chromatin-binding, or -regulatory protein