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Abnova
CCBE1 Polyclonal Antibody, MaxPab™
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Product Details
H00147372-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CCBE1 (AAH46645.1, 1 a.a. approximately 215 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MVKAGTCCAT CKEFYQMKQT VLQLKQKIAL LPNNAADLGK YITGDKVLAS NTYLPGPPGL PGGQGPPGSP GPKGSPGFPG MPGPPGQPGP RGSMGPMGPS PDLSHIKQGR RGPVGPPGAP GRDGSKGERG APGPRGSPGP PGSFDFLLLM LADIRNDITE LQEKVFGHRT HSSAEEFPLP QEFPSYPEAM DLGSGDDHPR RTETRDLRAP RDFYP
Target Information
The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region that is frequently found to be deleted in breast and prostate cancers. CCBE1 is a 406 amino acid secreted protein that contains two collagen-like domains and one calcium-binding epidermal growth factor (EGF-like) domain. In general, EGF-like domains include six cysteine residues that are usually involved in disulfide bonds. Calcium-binding EGF-like domains are subject to amino acid substitutions that disrupt their structure or calcium affinity, therefore altering protein function. Downregulation of the gene encoding CCBE1 is observed with high frequency in breast cancer, suggesting that loss of CCBE1 results in changes in cell adhesion and mobility due to its characterization as an extracellular protein. There are three named isoforms of CCBE1 which are produced as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagen and calcium-binding EGF domain-containing protein 1; FLJ30681; Full of fluid protein homolog; MGC50861
Gene Aliases: CCBE1; HKLLS1; KIAA1983; UNQ1921/PRO4395
UniProt ID: (Human) Q6UXH8
Entrez Gene ID: (Human) 147372
lymphangiogenesis
sprouting angiogenesis
positive regulation of vascular endothelial growth factor production
positive regulation of endothelial cell migration
positive regulation of protein processing
positive regulation of angiogenesis
venous blood vessel morphogenesis
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of lymphangiogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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