Immunogen sequence: LITDISDFKR KMPDLPGAVD EPYDRRFVKW MIKNKGLVAI PVSIFYSVPH QKHFDHYIRF CFVKDEATLQ AMDEKLRKWK VEL
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 82%.
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene.
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Protein Aliases: beta-lysase, kidney; CCBL1; cysteine conjugate beta lyase 1; cysteine conjugate-beta lyase, cytoplasmic; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); Cysteine-S-conjugate beta-lyase; Glutamine transaminase K; Glutamine--phenylpyruvate transaminase; glutamine-phenylpyruvate aminotransferase; GTK; KATI; kyneurenine aminotransferase; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; Kynurenine--oxoglutarate transaminase 1; Kynurenine--oxoglutarate transaminase I
Gene Aliases: CCBL1; GTK; KAT1; KATI; KYAT1
UniProt ID: (Human) Q16773
Entrez Gene ID: (Human) 883