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Invitrogen
CCDC115 Polyclonal Antibody
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Product Details
PA5-56987
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCDC115. Recombinant protein control fragment (Product #RP-96090).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PREAGLRRRK GPTKTPEPES SEAPQDPLNW FGILVPHSLR QAQASFRDGL QLAADIASLQ NRIDWGRSQL RGLQEKLKQL EP
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 84%.
Target Information
The CCDC115 gene encodes a protein known as coiled-coil domain-containing protein 115, which is involved in cellular processes related to membrane trafficking and Golgi apparatus function. CCDC115 is integral to maintaining Golgi homeostasis and is implicated in the functioning of the vacuolar H+-ATPase (V-ATPase) proton pump, critical for acidifying intracellular compartments. Mutations in CCDC115 have been associated with a genetic condition known as congenital disorder of glycosylation type IIo (CDG-IIo), which leads to defects in protein glycosylation. This disorder results in a spectrum of symptoms, including developmental delays, neurological impairments, and multi-systemic dysfunction due to improper glycosylation of proteins, impacting their stability and function. Research indicates that CCDC115's activity in ion transport and vacuolar acidification is essential for Golgi apparatus function and overall cellular homeostasis. Investigations into CCDC115 are crucial for understanding its role in glycosylation-related disorders and for developing potential therapeutic strategies to manage these conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: coiled-coil domain containing 115; Coiled-coil domain-containing protein 115; unnamed protein product; Vacuolar ATPase assembly protein VMA22
Gene Aliases: CCDC115; ccp1; CDG2O; VMA22
UniProt ID: (Human) Q96NT0
Entrez Gene ID: (Human) 84317
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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