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Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
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Protein Aliases: Coiled-coil domain-containing protein 141; Coiled-coil protein associated with myosin II and DISC1
Gene Aliases: CAMDI; CCDC141
UniProt ID: (Human) Q6ZP82
Entrez Gene ID: (Human) 285025
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