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Proteintech
CCDC151 Polyclonal Antibody
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Product Details
31680-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CCDC151 fusion protein Ag34867
Conjugate
Form
Liquid
Concentration
650 µg/mL
Amount
97.5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: NRLDSMEAEV VRTKHELEAL HVVNQEALNA RDIAKNQLQY LEETLVRERK KRERYISECK KRAEEKKLEN ERMERKTHRE HLLLQSDDTI QDSLHAKEEE LRQRWSMYQM EVIFGKVKDA TGTDETHSLV RRFLAQGDTF AQLETLKSEN EQTLVRLKQE KQQLQRELED LKYSGEATLV SQQKLQAEAQ ERLKKEERRH AEAKDQLERA LRAMQVAKDS LEHLASKLIH ITVEDGRFAG KELDPQADNY VPNLLGLVEE KLLKLQAQLQ GHDVQEMLCH IANREFLASL EGRLPEYNTR IALPLATSKD KFFDEESEEE DNEVVTRASL KIRSQKLIES HKKHRRSRRS
Target Information
CCDC151 (Coiled-Coil Domain-Containing 151) is a gene located on chromosome 19p13.2 that encodes a protein essential for the assembly and function of motile cilia. The protein is highly conserved across species with motile cilia and is the vertebrate ortholog of the Chlamydomonas ODA10 gene. CCDC151 is crucial for the assembly and docking of outer dynein arms (ODAs) on the axoneme of cilia, which are necessary for ciliary beating and motility. Mutations in CCDC151 have been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory infections, abnormal organ positioning (situs inversus), and infertility due to defective ciliary movement. Studies in zebrafish and mouse models have demonstrated that mutations in CCDC151 lead to a spectrum of situs defects and complex heart abnormalities. These findings underscore the pivotal role of CCDC151 in ciliary function and its implications in human health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coiled-coil domain containing 151; Coiled-coil domain-containing protein 151; Outer dynein arm-docking complex subunit 3; unnamed protein product
Gene Aliases: AI644415; b2b1885Clo; C330001K17Rik; CCDC151; CILD30; ODA10; ODAD3; RGD1310048
UniProt ID: (Mouse) Q8BSN3, (Human) A5D8V7
Entrez Gene ID: (Rat) 315465, (Mouse) 77609, (Human) 115948
cilium movement
outer dynein arm assembly
regulation of cilium assembly
cell morphogenesis
spermatogenesis
single fertilization
determination of left/right symmetry
brain development
heart development
cell projection organization
sperm motility
multicellular organism growth
cilium organization
homeostasis of number of cells
epithelial cilium movement involved in determination of left/right asymmetry
determination of heart left/right asymmetry
seminiferous tubule development
cerebrospinal fluid circulation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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