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Proteintech
CCDC8 Polyclonal Antibody
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Product Details
27194-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CCDC8 Fusion Protein Ag25794 (60-196 aa encoded by BC025243)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Amount
55.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EKSTPHPPQ PPKKPKEPRV RRRVQQMVTP PPRLVVGTYD SSNASDSEFS DFETSRDKSR QGPRRGKKVR KMPVSYLGSK FLGSDLESED DEELVEAFLR RQEKQPSAPP ARRRVNLPVP MFEDNLGPQL SKADRWRE (60-196 aa encoded by BC025243 )
Target Information
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coiled-coil domain-containing protein 8; protein phosphatase 1, regulatory subunit 20; unnamed protein product
Gene Aliases: 3M3; CCDC8; p90; PPP1R20
UniProt ID: (Human) Q9H0W5
Entrez Gene ID: (Human) 83987
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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