PA3-116 detects CCK1-Receptor in human samples.
PA3-116 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry procedures. By Western blot, this antibody detects an ~80-90 kDa protein representing CCK1-Receptor in human samples. In immunohistochemistry, PAC1 immunoreactivity is predominantly localized at the plasma membrane and in cells of the gastric mucosa, myenteric ganglion cells, myenteric nerve fibers in the gasrtointestinal tract.
PA3-116 immunogen is a synthetic peptide, KLH conjugated, corresponding to the residues T(409) G A S L S R F S Y S H M S A S V P P Q (428) of human VPAC2 receptor.
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCK-A receptor; CCK-AR; CCK1-R; ccka receptor; Cholecystokinin receptor type A; cholecystokinin type-A receptor; Cholecystokinin-1 receptor; HGNC:1570
Gene Aliases: CCK-A; CCK1-R; CCK1R; CCKAR; CCKRA
UniProt ID: (Human) P32238
Entrez Gene ID: (Human) 886