PA3-116 detects CCK1-Receptor in human samples.
PA3-116 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry procedures. By Western blot, this antibody detects an ~80-90 kDa protein representing CCK1-Receptor in human samples. In immunohistochemistry, PAC1 immunoreactivity is predominantly localized at the plasma membrane and in cells of the gastric mucosa, myenteric ganglion cells, myenteric nerve fibers in the gasrtointestinal tract.
PA3-116 immunogen is a synthetic peptide, KLH conjugated, corresponding to the residues T(409) G A S L S R F S Y S H M S A S V P P Q (428) of human VPAC2 receptor.
The CCK1 receptor is a member of a family of G protein- coupled receptors that mediate the effects of cholecystokinin (CCK), a peptide hormone in the gastrointestinal tract. CCK1 receptors have been found to function in various tissues, including the gall bladder, gastric smooth muscle cells and mucosa, myenteric neurons, and the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCK-A receptor; CCK-AR; CCK1-R; Cholecystokinin receptor type A; cholecystokinin type-A receptor; Cholecystokinin-1 receptor
Gene Aliases: CCK-A; CCK1-R; CCK1R; CCKAR; CCKRA
UniProt ID: (Human) P32238
Entrez Gene ID: (Human) 886