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Invitrogen

CCL21 Polyclonal Antibody

View all (22) CCL21 antibodies

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CCL21 Polyclonal Antibody

Product Details

PA5-23643

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 23-52 amino acids from the central region of human CCL21
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

200 µg

Purification

Antigen affinity chromatography, Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2541143

Target Information

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 6 Ckine; 6Ckine; 6Ckine; CC chemokine; beta chemokine exodus-2; Beta-chemokine exodus-2; C-C motif chemokine 21; C-C motif chemokine 21a; C-C motif chemokine 21b; C-C motif chemokine 21c; CC chemokine 6Ckine-ser; CCL21; Ccl21-leu; CCL21-Ser; chemokine (C-C motif) ligand 21; Efficient Chemoattractant for Lymphocytes; exodus-2; secondary lymphoid organ chemokine; secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; small inducible cytokine A21; small inducible cytokine A21a; small inducible cytokine A21c; small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21; Small-inducible cytokine A21a; Small-inducible cytokine A21b; Small-inducible cytokine A21c; TCA4; Thymus-derived chemotactic agent 4; unnamed protein product

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Gene Aliases: 6CKBAC1; 6CKBAC2; 6Ckine; AI159701; ALP; AW987545; CCL21; Ccl21a; Ccl21b; Ccl21c; CKb9; ECL; exodus-2; plt; SCYA21; SCYA21a; Scya21b; Scya21c; SLC; TCA4; UNQ784/PRO1600

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UniProt ID: (Human) O00585, (Mouse) P84444, (Mouse) P86793

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Entrez Gene ID: (Human) 6366, (Mouse) 18829, (Mouse) 100042493, (Mouse) 65956

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Function(s)
cytokine activity protein binding chemokine activity CCR7 chemokine receptor binding chemokine receptor binding CCR chemokine receptor binding cytokine intercellular signal molecule
Process(es)
establishment of T cell polarity immunological synapse formation positive regulation of cell-matrix adhesion dendritic cell chemotaxis positive regulation of dendritic cell antigen processing and presentation chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway cell-cell signaling positive regulation of glycoprotein biosynthetic process positive regulation of T cell chemotaxis cell migration positive regulation of cell migration positive regulation of actin filament polymerization positive regulation of pseudopodium assembly T cell costimulation ruffle organization killing of cells of other organism positive regulation of cell adhesion mediated by integrin mesangial cell-matrix adhesion chemokine (C-C motif) ligand 21 signaling pathway CCL21-activated CCR7 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade eosinophil chemotaxis positive regulation of receptor-mediated endocytosis cell maturation positive regulation of chemotaxis release of sequestered calcium ion into cytosol positive regulation of filopodium assembly positive regulation of protein kinase B signaling cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to prostaglandin E stimulus positive regulation of neutrophil chemotaxis dendritic cell dendrite assembly positive regulation of phospholipase C/protein kinase C signal transduction negative regulation of leukocyte tethering or rolling cellular response to chemokine positive regulation of cell motility positive regulation of T cell migration positive regulation of myeloid dendritic cell chemotaxis negative regulation of dendritic cell dendrite assembly negative regulation of dendritic cell apoptotic process lymph node development induction of positive chemotaxis leukocyte chemotaxis negative regulation of myeloid cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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