CCL27 gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C motif chemokine 27; CC chemokine ILC; chemokine (C-C motif) ligand 27; CTACK; cutaneous T-cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL-11 R-alpha-locus chemokine; IL-11 Ralpha-locus chemokine; Skinkine; small inducible cytokine subfamily A (Cys-Cys), member 27; Small-inducible cytokine A27
Gene Aliases: ALP; CCL27; CTACK; CTAK; ESKINE; ILC; PESKY; SCYA27
UniProt ID: (Human) Q9Y4X3
Entrez Gene ID: (Human) 10850