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Invitrogen

CCL3 Polyclonal Antibody

View all (43) CCL3 (MIP-1 alpha) antibodies

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CCL3 Polyclonal Antibody

Product Details

PA5-96722

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.98 mg/mL

Amount

198 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808524

Product Specific Information

Positive Samples: Mouse brain, Rat brain

Immunogen sequence: SLAADTPTAC CFSYTSRQIP QNFIADYFET SSQCSKPGVI FLTKRSRQVC ADPSEEWVQK YVSDLELSA

Target Information

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; G0S19-1 peptide precursor; H-MIP-1-alpha; Heparin-binding chemotaxis protein; L2G25B; LD78-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); Macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP-1 alpha; MIP-1-alpha; MIP1 (a); mip1 alpha; PAT 464.1; RP23-320E6.7; SIS-alpha; SIS-beta; small inducible cytokine A3; small inducible cytokine A3 (homologous to mouse Mip-1a); Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; TY-5

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Gene Aliases: AI323804; CCL3; G0S19-1; LD78; LD78ALPHA; MIP-1-alpha; MIP-1a; MIP-1alpha; MIP1-(a); MIP1-alpha; MIP1A; SCI; SCYA3

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UniProt ID: (Human) P10147, (Mouse) P10855, (Rat) P50229

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Entrez Gene ID: (Human) 6348, (Mouse) 20302, (Rat) 25542

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Function(s)
protein kinase activity cytokine activity protein binding chemokine activity phospholipase activator activity kinase activity CCR1 chemokine receptor binding CCR5 chemokine receptor binding chemoattractant activity identical protein binding CCR chemokine receptor binding calcium-dependent protein kinase C activity heparin binding cytokine intercellular signal molecule
Process(es)
MAPK cascade osteoblast differentiation cell activation monocyte chemotaxis calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response immune response cytoskeleton organization cell-cell signaling regulation of cell shape response to toxic substance positive regulation of gene expression negative regulation of gene expression T cell chemotaxis release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-mediated signaling signaling positive regulation of cell migration negative regulation of bone mineralization neutrophil chemotaxis positive regulation of interleukin-1 beta production positive regulation of tumor necrosis factor production eosinophil degranulation positive regulation of neuron apoptotic process astrocyte cell migration negative regulation by host of viral transcription negative regulation of osteoclast differentiation eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis positive regulation of inflammatory response regulation of behavior positive regulation of calcium-mediated signaling positive chemotaxis positive regulation of protein kinase B signaling positive regulation of calcium ion transport regulation of sensory perception of pain cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade response to cholesterol cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor granulocyte chemotaxis positive regulation of calcium ion import positive regulation of microglial cell activation positive regulation of microglial cell migration positive regulation of natural killer cell chemotaxis positive regulation of cytosolic calcium ion concentration leukocyte chemotaxis positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of interleukin-1 beta secretion protein phosphorylation lipopolysaccharide-mediated signaling pathway response to drug positive regulation of catalytic activity protein kinase B signaling cellular response to organic cyclic compound
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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