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          • Primary Antibodies ›
          • CCL5 (RANTES) Antibodies

          Bioss

          CCL5/RANTES Polyclonal Antibody

          View all (35) CCL5 (RANTES) antibodies

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          Cite CCL5/RANTES Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          CCL5/RANTES Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          CCL5/RANTES Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          CCL5/RANTES Antibody (BS-1324R) in IHC (P)

          Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-CCL5/RANTES Polyclonal Antibody, Unconjugated (bs-1324R) at 1:200 followed by conjugation to the secondary antibody and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CCL5/RANTES Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          CCL5/RANTES Polyclonal Antibody

          Product Details

          BS-1324R

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Bovine, Guinea pig, Human, Mouse, Pig

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human CCL5, amino acids 62-91.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: beta-chemokine RANTES; C-C motif chemokine 5; CC chemokine; chemokine (C-C motif) ligand 5; EoCP; Eosinophil chemotactic cytokine; MGC17164; MuRantes; OTTHUMP00000197106; regulated upon activation, normally T-expressed, and presumably secreted; SIS δ; SIS-delta; SISδ; small inducible cytokine A5; small inducible cytokine subfamily A (Cys-Cys), member 5; Small-inducible cytokine A5; T cell-specific protein P228; T cell-specific protein precursor; T-cell specific protein p288; T-cell-specific protein RANTES; TCP228; unnamed protein product

          View more View less

          Gene Aliases: CCL5; D17S136E; eoCP; MuRantes; RANTES; SCYA5; SIS-delta; SISd; TCP228

          View more View less

          UniProt ID: (Human) P13501, (Bovine) O97919, (Guinea pig) P97272, (Mouse) P30882

          View more View less

          Entrez Gene ID: (Human) 6352, (Pig) 396613, (Bovine) 327712, (Guinea pig) 100135495, (Mouse) 20304

          View more View less

          Function(s)
          phosphatidylinositol phospholipase C activity protein kinase activity cytokine activity protein binding chemokine activity phospholipase activator activity receptor signaling protein tyrosine kinase activator activity CCR1 chemokine receptor binding CCR4 chemokine receptor binding CCR5 chemokine receptor binding chemoattractant activity chemokine receptor binding identical protein binding protein homodimerization activity chemokine receptor antagonist activity CCR chemokine receptor binding protein self-association heparin binding cytokine intercellular signal molecule
          Process(es)
          dendritic cell chemotaxis monocyte chemotaxis regulation of chronic inflammatory response calcium ion transport cellular calcium ion homeostasis exocytosis chemotaxis inflammatory response immune response leukocyte cell-cell adhesion G-protein coupled receptor signaling pathway cell-cell signaling response to virus response to toxic substance positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis positive regulation of smooth muscle cell migration positive regulation of cell migration phospholipase D-activating G-protein coupled receptor signaling pathway positive regulation of TOR signaling positive regulation of cell-cell adhesion mediated by integrin response to cytokine positive regulation of homotypic cell-cell adhesion response to tumor necrosis factor chemokine (C-C motif) ligand 5 signaling pathway positive regulation of T cell proliferation neutrophil activation negative regulation by host of viral transcription cellular response to fibroblast growth factor stimulus positive regulation of viral genome replication negative regulation of viral genome replication positive regulation of innate immune response negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of cell adhesion positive regulation of translational initiation eosinophil chemotaxis macrophage chemotaxis positive regulation of smooth muscle cell proliferation epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of insulin secretion regulation of T cell activation positive chemotaxis positive regulation of protein kinase B signaling positive regulation of calcium ion transport antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway negative regulation of chemokine-mediated signaling pathway negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of monocyte chemotaxis receptor signaling pathway via STAT cellular response to virus positive regulation of neuroinflammatory response positive regulation of STAT cascade negative regulation of macrophage apoptotic process positive regulation of T cell migration positive regulation of natural killer cell chemotaxis cell chemotaxis regulation of neuron death MAPK cascade positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of cellular biosynthetic process activation of phospholipase D activity lipopolysaccharide-mediated signaling pathway positive regulation of tyrosine phosphorylation of STAT protein protein kinase B signaling positive regulation of protein tyrosine kinase activity cellular response to organic cyclic compound positive regulation of defense response to virus by host positive regulation of gene expression pseudopodium assembly positive regulation of fever generation response to interferon-gamma T-helper 1 cell diapedesis positive regulation of phosphorylation cellular protein complex assembly positive regulation of neuron differentiation positive regulation of osteoclast differentiation positive regulation of angiogenesis lymphocyte chemotaxis protein tetramerization negative regulation of cell death positive regulation of mast cell chemotaxis extracellular negative regulation of signal transduction negative regulation of neuron death negative regulation of receptor activity positive regulation of chemokine (C-X-C motif) ligand 2 production
          It has to be done as per old AB suggested Products section.

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