This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated. View Details
In sandwich ELISAs, less than 0.02% cross-reactivity with recombinant human RANTES, recombinant mouse RANTES, and recombinant cotton rat RANTES is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
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Protein Aliases: beta-chemokine RANTES; C-C motif chemokine 5; D17S136E; eoCP; eosinophil chemotactic cytokine; MGC17164; SCYA5; SISd; small inducible cytokine A5; Small-inducible cytokine A5; t cell-specific protein P228; T-cell specific protein p288; T-cell-specific protein RANTES
Gene Aliases: CCL5; RANTES; SCYA5
UniProt ID: (Cat) Q8SQ40
Entrez Gene ID: (Cat) 493689