Immunogen sequence: SPENNDLISYN SVWVACQQMP QIPRDNKAAA LLMLTKNVDF VKDAHEEMEQ AVEECDPYSG LLNDTEENNS DNHNHEDDVL GFPSNQD
Highest antigen sequence identity to the following orthologs - mouse 81%, rat 76%.
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.
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Protein Aliases: cyclin D-type binding-protein 1; Cyclin-D1-binding protein 1; D-type cyclin-interacting protein 1; grap2 and cyclin D interacting protein; Grap2 and cyclin-D-interacting protein; Human homolog of Maid
Gene Aliases: CCNDBP1; DIP1; GCIP; HHM
UniProt ID: (Human) O95273
Entrez Gene ID: (Human) 23582