Invitrogen

CCNK Polyclonal Antibody

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CCNK Antibody in Western Blot (WB) — Western blot analysis of CCNK expression in K562 cell lysate using a CCNK Polyclonal Antibody (Product # PA5-67792).

Product Details

PA5-67792

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthesized peptide derived from human CCNK. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	affinity chromatography
Storage buffer	PBS, pH 7.4, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C
RRID	AB_2692190

Product Specific Information

Predicted to react with Mouse samples.

Target Information

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cyclin-K

Gene Aliases: AW123198; AW413594; CCNK; CPR4; CycK

UniProt ID: (Human) O75909

Entrez Gene ID: (Human) 8812, (Mouse) 12454

Molecular Function: kinase activator

regulation of cyclin-dependent protein serine/threonine kinase activity transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter protein phosphorylation cellular response to DNA damage stimulus mitotic nuclear division snRNA transcription from RNA polymerase II promoter negative regulation by host of viral genome replication positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription from RNA polymerase II promoter cell division negative regulation of cell cycle arrest positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues in utero embryonic development transcription, DNA-templated regulation of transcription, DNA-templated cell cycle

Process(es)

protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding RNA polymerase II carboxy-terminal domain kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding