Invitrogen

CCNK Polyclonal Antibody

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CCNK Antibody in Western Blot (WB) — Western blot analysis of CCNK expression in K562 cell lysate using a CCNK Polyclonal Antibody (Product # PA5-67792).

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human CCNK.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

RRID

AB_2692190

Product Specific Information

Predicted to react with Mouse samples.

Target Information

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cyclin-K

Gene Aliases: AW123198; AW413594; CCNK; CPR4; CycK

UniProt ID: (Human) O75909

Entrez Gene ID: (Human) 8812, (Mouse) 12454

Molecular Function: RNA binding protein enzyme modulator kinase activator kinase modulator mRNA processing factor nucleic acid binding transcription cofactor transcription factor

regulation of cyclin-dependent protein serine/threonine kinase activity transcription from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter protein phosphorylation cellular response to DNA damage stimulus mitotic nuclear division snRNA transcription from RNA polymerase II promoter negative regulation by host of viral genome replication positive regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of transcription from RNA polymerase II promoter cell division negative regulation of cell cycle arrest positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues in utero embryonic development transcription, DNA-templated regulation of transcription, DNA-templated cell cycle

Process(es)

protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding RNA polymerase II carboxy-terminal domain kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein kinase binding