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Fabgennix
CCR1 Polyclonal Antibody
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Product Details
CCR1-112AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1-50 on human CCR1 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C motif) receptor 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES receptor; RANTES-R
Gene Aliases: CCR1; CD191; CKR-1; CKR1; CMKBR1; CMKR1; HM145; MIP1aR; SCYAR1
UniProt ID: (Human) P32246
Entrez Gene ID: (Human) 1230
dendritic cell chemotaxis
monocyte chemotaxis
calcium ion transport
cellular calcium ion homeostasis
exocytosis
chemotaxis
inflammatory response
immune response
cell adhesion
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
I-kappaB kinase/NF-kappaB signaling
cell-cell signaling
response to wounding
negative regulation of gene expression
cytokine-mediated signaling pathway
calcium-mediated signaling
signal transduction involved in regulation of gene expression
positive regulation of cell migration
negative regulation of bone mineralization
positive regulation of osteoclast differentiation
positive regulation of inflammatory response
positive regulation of calcium ion transport
cell chemotaxis
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
positive regulation of monocyte chemotaxis
positive regulation of neuroinflammatory response
negative regulation of cytokine production involved in inflammatory response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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