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Invitrogen
CCR1 Polyclonal Antibody
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Product Details
PA5-33392
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human CCR1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Monkey, Hamster (89%) Marmoset, Mouse (83%).
Target Information
Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C motif) receptor 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES receptor; RANTES-R
Gene Aliases: CCR1; CD191; CKR-1; CKR1; CMKBR1; CMKR1; HM145; MIP1aR; SCYAR1
UniProt ID: (Human) P32246
Entrez Gene ID: (Human) 1230
dendritic cell chemotaxis
calcium ion transport
cellular calcium ion homeostasis
exocytosis
chemotaxis
inflammatory response
immune response
cell adhesion
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
response to wounding
negative regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of cell migration
negative regulation of bone mineralization
positive regulation of osteoclast differentiation
positive regulation of calcium ion transport
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of monocyte chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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