Proteintech

CCR10 Polyclonal Antibody

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CCR10 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human spleen using 22071-1-AP (CCR10 antibody) at dilution of 1:50 (under 40x lens).

CCR10 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 22071-1-AP (CCR10 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CCR10 Antibody in Flow Cytometry (Flow) — 1X10^6 HepG2 cells were stained with 0.2ug CCR10 antibody (22071-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1000.

Product Details

22071-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Flow Cytometry (Flow)	0.2 µg/1x10^6 cells	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	CCR10 Fusion Protein Ag17212 (1-82 aa encoded by BC099840)
Conjugate	Unconjugated
Form	Liquid
Concentration	0.44 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MGTEATEQV SWGHYSGDEE DAYSAEPLPE LCYKADVQAF SRAFQPSVSL TVAALGLAGN GLVLATHLAA RRAARSPTSA HLL (1-82 aa encoded by BC099840)

Target Information

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27; CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-C chemokine receptor type 10; C-C CKR-10; CC chemokine receptor 10; CC-CKR-10; CCR-10; chemokine (C-C motif) receptor 10; Chemokine C-C receptor 9; G protein-coupled receptor 2; G-protein coupled receptor 2; MGC151420; RP23-281C18.3

Gene Aliases: CCR10; Cmkbr9; GPR2

UniProt ID: (Human) P46092, (Mouse) Q9JL21

Entrez Gene ID: (Human) 2826, (Mouse) 12777

Function(s)

chemotaxis immune response G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration chemokine-mediated signaling pathway signal transduction

Process(es)

G-protein coupled receptor activity C-C chemokine receptor activity signal transducer activity chemokine receptor activity protein binding