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The immunogen sequence is 100% identical in human and mouse.
Suggested positive control: A-375 or MCF-7, antigen standard for CCR10 (transient overexpression lysate).
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27; CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C chemokine receptor type 10; C-C CKR-10; CC chemokine receptor 10; CC-CKR-10; CCR-10; chemokine (C-C motif) receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2; MGC151420; RP23-281C18.3
Gene Aliases: CCR10; GPR2
UniProt ID: (Human) Q6T7X2
Entrez Gene ID: (Human) 2826
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