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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 350-362 of human CCR10.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:1000|
|Immunohistochemistry (Frozen) (IHC (F))||1:10-1:2000|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The immunogen sequence is 100% identical in human and mouse.
Suggested positive control: A-375 or MCF-7, antigen standard for CCR10 (transient overexpression lysate).
Recently, a function has been assigned to a previously identified orphan chemokine receptor, GPR-2. This receptor, also called CCR10, binds with monocyte chemoattractant protein (MCP)-1, MCP-3 and MIP-1 beta. CCR10 is expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells, T cells as well as in skin-derived Langerhans cells. CCR10 may play a role in both skin homeostasis as well as a potential role in inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C-C Chemokine Receptor 10; C-C CKR-10; CC chemokine receptor 10; CC-CKR-10; CCR-10; chemokine (C-C motif) receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2