Fabgennix

CCR2 Polyclonal Antibody, FITC

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Tech Support
CCR2 Polyclonal Antibody, FITC

Product Details

CCR2-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 20-70 on human CCR2 protein.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-C chemokine receptor type 2; C-C CKR-2; Cc-ckr2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

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Gene Aliases: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R

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UniProt ID: (Human) P41597

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Entrez Gene ID: (Human) 729230

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Function(s)
chemokine receptor activity C-C chemokine receptor activity protein kinase binding CCR2 chemokine receptor binding protein homodimerization activity chemokine (C-C motif) ligand 5 binding
Process(es)
blood vessel remodeling dendritic cell chemotaxis inflammatory response to antigenic stimulus positive regulation of T-helper 1 type immune response negative regulation of type 2 immune response cellular calcium ion homeostasis chemotaxis inflammatory response immune response cellular defense response G-protein coupled receptor signaling pathway negative regulation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration JAK-STAT cascade aging response to wounding response to ionizing radiation regulation of vascular endothelial growth factor production positive regulation of gene expression positive regulation of T cell chemotaxis negative regulation of angiogenesis cytokine-mediated signaling pathway cellular homeostasis negative regulation of cell migration negative regulation of axon extension forebrain development positive regulation of fever generation response to lipopolysaccharide positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-6 production T-helper 17 cell chemotaxis positive regulation of tumor necrosis factor biosynthetic process defense response to bacterium negative regulation of eosinophil degranulation fat cell differentiation positive regulation of neuron differentiation positive regulation of alpha-beta T cell proliferation positive regulation of interleukin-1 beta secretion positive regulation of inflammatory response positive regulation of T cell activation positive regulation of apoptotic process by virus chemokine-mediated signaling pathway neuron death positive regulation of monocyte chemotaxis positive regulation of cell migration involved in sprouting angiogenesis positive regulation of immune complex clearance by monocytes and macrophages negative regulation of neural precursor cell proliferation positive regulation of monocyte extravasation positive regulation of CD8-positive, alpha-beta T cell extravasation positive regulation of astrocyte chemotaxis positive regulation of hematopoietic stem cell migration
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