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Invitrogen
CCR2 Polyclonal Antibody
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FIGURE: 1 / 2
CCR2 Antibody (PA5-112059) in WB
Western Blot analysis of CCR2 (CD192) using CCR2 Polyclonal Antibody (Product # PA5-112059) at a dilution of 1:500. Lane A: A431 Membrane Lysate, (Lysates/proteins at 30 µg per lane). The secondary antibody used was a Goat Anti-Rabbit IgG H&L (Dylight800) at 1:10000 dilution. Developed using the Odyssey technique and performed under reducing conditions. Predicted band size: 42 kDa. Observed band size: 48 kDa (We are unsure as to the identity of these extra bands).
Product Details
PA5-112059
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human CCR2/cd192
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 2; C-C CKR-2; Cc-ckr2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor; unnamed protein product
Gene Aliases: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R; PCLUD
UniProt ID: (Human) P41597
Entrez Gene ID: (Human) 729230
G-protein coupled receptor activity
chemokine receptor activity
protein binding
C-C chemokine receptor activity
cytokine binding
C-C chemokine binding
CCR2 chemokine receptor binding
chemokine (C-C motif) ligand 2 binding
chemokine (C-C motif) ligand 12 binding
chemokine (C-C motif) ligand 7 binding
identical protein binding
blood vessel remodeling
dendritic cell chemotaxis
monocyte chemotaxis
regulation of T cell cytokine production
positive regulation of T-helper 1 type immune response
negative regulation of type 2 immune response
cellular calcium ion homeostasis
chemotaxis
inflammatory response
immune response
humoral immune response
cellular defense response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
response to wounding
regulation of vascular endothelial growth factor production
positive regulation of T cell chemotaxis
negative regulation of angiogenesis
cytokine-mediated signaling pathway
sensory perception of pain
calcium-mediated signaling
cellular homeostasis
hemopoiesis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of tumor necrosis factor production
monocyte extravasation
T-helper 17 cell chemotaxis
negative regulation of eosinophil degranulation
regulation of T cell differentiation
positive regulation of alpha-beta T cell proliferation
homeostasis of number of cells within a tissue
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of T cell activation
positive regulation of synaptic transmission, glutamatergic
cell chemotaxis
leukocyte adhesion to vascular endothelial cell
chemokine-mediated signaling pathway
cellular response to cytokine stimulus
regulation of mononuclear cell migration
positive regulation of monocyte chemotaxis
positive regulation of immune complex clearance by monocytes and macrophages
inflammatory response to wounding
neutrophil clearance
positive regulation of cold-induced thermogenesis
positive regulation of glutamate receptor signaling pathway
positive regulation of leukocyte tethering or rolling
macrophage migration
regulation of macrophage migration
regulation of T cell migration
positive regulation of thymocyte migration
positive regulation of monocyte extravasation
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of astrocyte chemotaxis
positive regulation of hematopoietic stem cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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