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Invitrogen
CCR2 Polyclonal Antibody, DyLight™ 650
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Product Details
PA5-23039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Cat,
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to an N-terminal portion of the human CCR2 protein (within residues 20-100).
Conjugate
Excitation/Emission Max
651/673 nm
View spectra
Form
Liquid
Concentration
0.67 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
50mM sodium borate
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The immunogen sequence similarity with other species: Rhesus monkey and several other primate species (100%), Mouse (69%).
Target Information
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; Cc-ckr2; CCR-2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; chemokine receptor CCR2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Gene Aliases: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
UniProt ID: (Human) P41597, (Rat) O55193
Entrez Gene ID: (Bovine) 539002, (Cat) 100049057, (Human) 729230, (Rat) 60463
chemokine receptor activity
C-C chemokine receptor activity
protein kinase binding
CCR2 chemokine receptor binding
protein homodimerization activity
chemokine (C-C motif) ligand 5 binding
cytokine binding
chemokine binding
C-C chemokine binding
chemokine (C-C motif) ligand 2 binding
chemokine (C-C motif) ligand 12 binding
chemokine (C-C motif) ligand 7 binding
response to hypoxia
blood vessel remodeling
inflammatory response to antigenic stimulus
monocyte chemotaxis
positive regulation of T-helper 1 type immune response
negative regulation of type 2 immune response
cellular calcium ion homeostasis
inflammatory response
immune response
humoral immune response
cellular defense response
G-protein coupled receptor signaling pathway
regulation of vascular endothelial growth factor production
positive regulation of T cell chemotaxis
negative regulation of angiogenesis
cytokine-mediated signaling pathway
sensory perception of pain
cellular homeostasis
hemopoiesis
regulation of cell migration
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of tumor necrosis factor production
T-helper 17 cell chemotaxis
positive regulation of tumor necrosis factor biosynthetic process
negative regulation of eosinophil degranulation
positive regulation of MAPK cascade
positive regulation of alpha-beta T cell proliferation
positive regulation of inflammatory response
positive regulation of T cell activation
response to hyperoxia
chemokine-mediated signaling pathway
positive regulation of monocyte chemotaxis
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of monocyte extravasation
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of astrocyte chemotaxis
positive regulation of hematopoietic stem cell migration
dendritic cell chemotaxis
chemotaxis
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
aging
response to wounding
response to ionizing radiation
positive regulation of gene expression
negative regulation of cell migration
negative regulation of axon extension
forebrain development
positive regulation of fever generation
response to lipopolysaccharide
positive regulation of interleukin-6 production
defense response to bacterium
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of interleukin-1 beta secretion
positive regulation of apoptotic process by virus
neuron death
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
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