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Alomone Labs, LTD

CCR2 (extracellular) Polyclonal Antibody

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CCR2 (extracellular) Polyclonal Antibody

Product Details

ACR-072-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:300
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide RDAIVKVKEVHDE, corresponding to amino acid residues 183-195 of rat Gephyrin. Intracellular.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunogen sequence: RDAIVKVKEVHDE

Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; CC-CKR-2; Cc-ckr2; CCR-2; CD192; CD192 antigen; chemoattractant protein-1 receptor; chemokine (C-C) receptor 2; chemokine receptor CCR2; hCG_14621; JE/FIC receptor; MCP-1 receptor; Mcp1 receptor; Mcp1r; MIP-1 alphaR

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Gene Aliases: Cc-ckr-2; Ccr2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b; Cmkbr2; mJe-r

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UniProt ID: (Rat) O55193, (Mouse) P51683

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Entrez Gene ID: (Rat) 60463, (Mouse) 12772

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Function(s)
C-C chemokine receptor activity cytokine binding chemokine binding C-C chemokine binding CCR2 chemokine receptor binding chemokine (C-C motif) ligand 2 binding chemokine (C-C motif) ligand 12 binding chemokine (C-C motif) ligand 7 binding protein homodimerization activity signal transducer activity G-protein coupled receptor activity chemokine receptor activity protein binding
Process(es)
response to hypoxia blood vessel remodeling inflammatory response to antigenic stimulus monocyte chemotaxis positive regulation of T-helper 1 type immune response negative regulation of type 2 immune response cellular calcium ion homeostasis inflammatory response immune response humoral immune response cellular defense response G-protein coupled receptor signaling pathway regulation of vascular endothelial growth factor production positive regulation of T cell chemotaxis negative regulation of angiogenesis cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis hemopoiesis regulation of cell migration positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of tumor necrosis factor production T-helper 17 cell chemotaxis positive regulation of tumor necrosis factor biosynthetic process negative regulation of eosinophil degranulation positive regulation of MAPK cascade positive regulation of alpha-beta T cell proliferation positive regulation of inflammatory response positive regulation of T cell activation response to hyperoxia chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of monocyte extravasation positive regulation of CD8-positive, alpha-beta T cell extravasation positive regulation of astrocyte chemotaxis positive regulation of hematopoietic stem cell migration angiogenesis wound healing involved in inflammatory response chemotaxis signal transduction apoptotic cell clearance positive regulation of T-helper 1 cell differentiation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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