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Product Details
PA5-51094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the N-terminal region of human CD100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2636542
Product Specific Information
CD100 / SEMA4D Polyclonal Antibody detects endogenous levels of CD100 / SEMA4D protein.
Target Information
Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A8; BB18; CD100; GR3; M-Sema G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; Sema J; semaphorin H; Semaphorin-4D; Semaphorin-C-like 2; Semaphorin-J
Gene Aliases: C9orf164; CD100; coll-4; M-sema-G; SEMA4D; Semacl2; SEMAJ; Semcl2
UniProt ID: (Human) Q92854, (Mouse) O09126
Entrez Gene ID: (Human) 10507, (Rat) 306790, (Mouse) 20354
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
positive regulation of protein phosphorylation
immune response
cell adhesion
negative regulation of cell adhesion
regulation of cell shape
negative regulation of alkaline phosphatase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell migration
regulation of cell projection organization
negative regulation of apoptotic process
positive regulation of GTPase activity
ossification involved in bone maturation
negative regulation of osteoblast differentiation
positive regulation of collateral sprouting
regulation of dendrite morphogenesis
negative regulation of axon extension involved in axon guidance
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
leukocyte aggregation
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
multicellular organism development
positive regulation of axonogenesis
nervous system development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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