Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-27608 detects ITGB4 from human samples.
PA1-27608 may be successfully used in Western blot applications.
The PA1-27453 immunogen is a synthetic peptide corresponding to human Integrin beta-4.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD antigen CD104; CD104; CD104 antigen; GP150; Integrin beta-4
Gene Aliases: ITGB4
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