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CD105 Polyclonal Antibody
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FIGURE: 1 / 3
CD105 Antibody (BS-0579R) in IHC (P)
Paraformaldehyde-fixed, paraffin-embedded human colon cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CD105 Polyclonal Antibody, Unconjugated (bs-0579R) at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes... View More
Product Details
BS-0579R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CD105, amino acids 601-658.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD105; CD105 antigen; Cell surface MJ7/18 antigen; circulating isoform of endoglin TGF-beta receptor type III; Endoglin; endoglin precursor; ORW; soluble endoglin; transmembrane glycoprotein; unnamed protein product
Gene Aliases: AI528660; AI662476; CD105; Edg; END; Endo; ENG; HHT1; ORW1; S-endoglin
UniProt ID: (Human) P17813, (Mouse) Q63961
Entrez Gene ID: (Human) 2022, (Mouse) 13805, (Rat) 497010
transmembrane signaling receptor activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
coreceptor activity
receptor activator activity
type I transforming growth factor beta receptor binding
BMP binding
identical protein binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transforming growth factor beta-activated receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
transmembrane signal receptor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
vasculogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
heart looping
sprouting angiogenesis
positive regulation of systemic arterial blood pressure
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
cell adhesion
transforming growth factor beta receptor signaling pathway
heart development
negative regulation of gene expression
regulation of cardiac muscle cell apoptotic process
cell migration
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
extracellular matrix disassembly
regulation of cell adhesion
negative regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of BMP signaling pathway
dorsal aorta morphogenesis
wound healing
regulation of cell proliferation
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
cell motility
positive regulation of protein kinase B signaling
atrial cardiac muscle tissue morphogenesis
cell chemotaxis
positive regulation of SMAD protein import into nucleus
negative regulation of SMAD protein import into nucleus
detection of hypoxia
endocardial cushion to mesenchymal transition
vascular smooth muscle cell development
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
positive regulation of vascular smooth muscle cell differentiation
atrioventricular canal morphogenesis
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of cell proliferation involved in heart morphogenesis
positive regulation of protein phosphorylation
protein phosphorylation
transmembrane receptor protein serine/threonine kinase signaling pathway
positive regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of protein autophosphorylation
positive regulation of collagen biosynthetic process
intracellular signal transduction
negative regulation of nitric-oxide synthase activity
negative regulation of pathway-restricted SMAD protein phosphorylation
extracellular matrix constituent secretion
chronological cell aging
response to corticosteroid
response to statin
bone development
cellular response to mechanical stimulus
response to transforming growth factor beta
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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