|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human CD105 (Endoglin)|
|Storage buffer||PBS with sucrose, BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
Analyte Specific Reagent
Long-Term Expansion in Platelet Lysate Increases Growth of Peripheral Blood-Derived Endothelial-Colony Forming Cells and Their Growth Factor-Induced Sprouting Capacity.
MHCD10504 was used in flow cytometry to investigate how xenogeneic-free conditions affect the therapeutic capacity of peripheral blood-derived endothelial-colony cells.
|Tasev D,van Wijhe MH,Weijers EM,van Hinsbergh VW,Koolwijk P||PloS one (10:null)||2015|
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
MHCD10504 was used in flow cytometry to discuss the contribution of missense mutations in PDE3A to hypertension.
|Maass PG,Aydin A,Luft FC,Schächterle C,Weise A,Stricker S,Lindschau C,Vaegler M,Qadri F,Toka HR,Schulz H,Krawitz PM,Parkhomchuk D,Hecht J,Hollfinger I,Wefeld-Neuenfeld Y,Bartels-Klein E,Mühl A,Kann M,Schuster H,Chitayat D,Bialer MG,Wienker TF,Ott J,Rittscher K,Liehr T,Jordan J,Plessis G,Tank J,Mai K,Naraghi R,Hodge R,Hopp M,Hattenbach LO,Busjahn A,Rauch A,Vandeput F,Gong M,Rüschendorf F,Hübner N,Haller H,Mundlos S,Bilginturan N,Movsesian MA,Klussmann E,Toka O,Bähring S||Nature genetics (47:647)||2015|