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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Human CD105 (Endoglin)|
|Conjugate||Alexa Fluor® 488|
|Storage buffer||PBS with 4mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
Based on our testing, publications, and results reported from customers, the Alexa Fluor® 488 dye provides the best fluorescein (FITC) substitute.
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
Analyte Specific Reagent
Octacalcium phosphate ceramics combined with gingiva-derived stromal cells for engineered functional bone grafts.
MHCD10520 was used in flow cytometry to evaluate the osteogenic capacity of bone marrow mesenchymal stream cells and gingiva-derived mesenchymal stromal cells
|Zorin VL,Komlev VS,Zorina AI,Khromova NV,Solovieva EV,Fedotov AY,Eremin II,Kopnin PB||Biomedical materials (Bristol, England) (9:null)||2014|
CD105 antigen, CD105, END, HHT1, ORW, ORW1, ENG
ORW1, END, HHT1
Signal transduction Cell surface receptor mediated signal transduction Receptor protein serine/threonine kinase signaling pathway Cell communication Cell adhesion-mediated signaling Developmental processes Mesoderm development Heart development Angiogenesis Blood circulation and gas exchange Cell adhesion