CD109 is a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta).
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Protein Aliases: 150 kDa TGF-beta-1-binding protein; activated T-cell marker CD109; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; CD109; CD109 antigen; Gov platelet alloantigens; GPI-anchored alpha 2 macroglobulin-related protein; GPI-anchored alpha-2 macroglobulin-related protein; p180; Platelet-specific Gov antigen; r150; RP11-525G3.1
Gene Aliases: 9930012E15Rik; AI480638; CD109; CPAMD7; GARP; p180; r150