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OriGene
CD130 Polyclonal Antibody
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FIGURE: 1 / 1
CD130 Antibody (TA590116) in WB
Western Blot: CD130 Antibody - was performed using affinity purified SEQer IL6ST antibody, aa (254-353) antibody. The lanes contain 5-30 µg of a whole cell extract. Final concentration of antibodies = 0.1 µg/mL (1:10,000 dilution). The blot was probed overnight with the SEQer IL6ST antibody, aa (254-353) antibody. Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec). The protein was detected as represented by the ba... View More
Product Details
TA590116
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNA immunization. This antibody is specific for the Middle Region of the target protein.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD130; CD130 antigen; CDw130; gp130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL6R-beta; interleukin receptor beta chain; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; LIF receptor/IL-6 receptor complex component; Membrane glycoprotein 130; membrane glycoprotein gp130; Oncostatin-M receptor subunit alpha; soluble receptor
Gene Aliases: CD130; CDW130; GP130; HIES4; HIES4A; HIES4B; IL-6RB; IL6ST; IMD94; sGP130; STWS2
UniProt ID: (Human) P40189
Entrez Gene ID: (Human) 3572
cytokine receptor activity
ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-11 receptor activity
leukemia inhibitory factor receptor activity
oncostatin-M receptor activity
ciliary neurotrophic factor receptor binding
interleukin-6 receptor binding
protein binding
coreceptor activity
growth factor binding
cytokine binding
interleukin-11 binding
interleukin-6 binding
protein tyrosine kinase activator activity
identical protein binding
interleukin-27 receptor activity
scaffold protein binding
positive regulation of acute inflammatory response
positive regulation of adaptive immune response
glycogen metabolic process
signal transduction
JAK-STAT cascade
positive regulation of cell proliferation
regulation of Notch signaling pathway
positive regulation of vascular endothelial growth factor production
positive regulation of cardiac muscle hypertrophy
cytokine-mediated signaling pathway
cell differentiation
response to cytokine
interleukin-11-mediated signaling pathway
oncostatin-M-mediated signaling pathway
positive regulation of T cell proliferation
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
positive regulation of astrocyte differentiation
leukemia inhibitory factor signaling pathway
intestinal epithelial cell development
interleukin-6-mediated signaling pathway
negative regulation of interleukin-6-mediated signaling pathway
interleukin-27-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
T-helper 17 cell lineage commitment
receptor signaling pathway via STAT
positive regulation of platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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