Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
A recommended positive control is Jurkat cell lysate.
Multiple isoforms of PROM1 are known to exist.
The CD133 (AC133) antigen is a 97 kDa glycoprotein, with 5 transmembrane domains, that shows up as a 120 kDa band on protein gels due to glycosylation. CD133 is a cell surface marker expressed by immature hematopoietic stem cells but not mature blood cells. In addition to hematopoietic stem and progenitor cells, CD133 has been found to be a marker for other stem and progenitor cells including neural and embryonic stem cells. CD133 has been shown to be expressed in cancers, including some leukemias and brain tumors, that may be derived from stem cells. Low level expression could also be detected in the kidney, pancreas, placenta, and fetal liver. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of the CD133 gene is also associated with several types of cancer. CD133 is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner, and multiple transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antigen AC133; Antigen AC133 homolog; antigen CD133; CD133; fudenine; hematopoietic stem cell antigen; hProminin; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c; Lamp2; Mac3; Prominin-1; prominin-like 1; Prominin-like protein 1; Prominin1
Gene Aliases: 4932416E19Rik; AC133; CD133; CORD12; MCDR2; MSTP061; Prom; Prom-1; PROM1; PROML1; RP41; STGD4
UniProt ID: (Human) O43490, (Mouse) O54990
Entrez Gene ID: (Human) 8842, (Mouse) 19126, (Rat) 60357
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support