|Flow Cytometry (Flow)||Assay-Dependent|
|Miscellaneous PubMed (MISC)||See 33 publications below|
|Flow Cytometry (Flow)||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Non-human primate , Human Rhesus monkey|
|Host / Isotype||Mouse / IgG2a|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, store in dark|
CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
Analyte Specific Reagent
Protein Aliases: CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein
Gene Aliases: CD14
UniProt ID: (Human) P08571
Entrez Gene ID: (Human) 929
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