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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||PBS with 10% sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The TRI-COLOR® conjugate is a tandem R-phycoerythrin (PE)-Cy5® conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
Analyte Specific Reagent
Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.
MHCD1406 was used in flow cytometry to examine the effects of eltrombopag on leukemia cell proliferation and the mechanism of its antiproliferative effects.
|Roth M,Will B,Simkin G,Narayanagari S,Barreyro L,Bartholdy B,Tamari R,Mitsiades CS,Verma A,Steidl U||Blood (120:386)||2012|
The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells.
MHCD1406 was used in flow cytometry to characterize a chemically synthesized fragment of IL-2.
|Eckenberg R,Rose T,Moreau JL,Weil R,Gesbert F,Dubois S,Tello D,Bossus M,Gras H,Tartar A,Bertoglio J,Chouaïb S,Goldberg M,Jacques Y,Alzari PM,Thèze J||The Journal of experimental medicine (191:529)||2000|
Cytokine signatures of innate and adaptive immunity in 17DD yellow fever vaccinated children and its association with the level of neutralizing antibody.
MHCD1406 was used in flow cytometry to discuss the live attenuated yellow fever vaccines.
|Luiza-Silva M,Campi-Azevedo AC,Batista MA,Martins MA,Avelar RS,da Silveira Lemos D,Bastos Camacho LA,de Menezes Martins R,de Lourdes de Sousa Maia M,Guedes Farias RH,da Silva Freire M,Galler R,Homma A,Leite Ribeiro JG,Campos Lemos JA,Auxiliadora-Martins M,Eloi-Santos SM,Teixeira-Carvalho A,Martins-Filho OA||The Journal of infectious diseases (204:873)||2011|
Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors.
MHCD1406 was used in flow cytometry to characterize the cells present in the cutaneous blister fluid patients with toxic epidermal necrolysis.
|Le Cleach L,Delaire S,Boumsell L,Bagot M,Bourgault-Villada I,Bensussan A,Roujeau JC||Clinical and experimental immunology (119:225)||2000|
CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein