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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Storage buffer||PBS with 10% sucrose|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C, store in dark|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 2 publications below|
The TRI-COLOR® conjugate is a tandem R-phycoerythrin (PE)-Cy5® conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source-the 488 nm line of the argon-ion laser.
CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
Analyte Specific Reagent
Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.
MHCD1406 was used in flow cytometry to examine the effects of eltrombopag on leukemia cell proliferation and the mechanism of its antiproliferative effects.
|Roth M,Will B,Simkin G,Narayanagari S,Barreyro L,Bartholdy B,Tamari R,Mitsiades CS,Verma A,Steidl U||Blood (120:386)||2012|
The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells.
MHCD1406 was used in flow cytometry to characterize a chemically synthesized fragment of IL-2.
|Eckenberg R,Rose T,Moreau JL,Weil R,Gesbert F,Dubois S,Tello D,Bossus M,Gras H,Tartar A,Bertoglio J,Chouaïb S,Goldberg M,Jacques Y,Alzari PM,Thèze J||The Journal of experimental medicine (191:529)||2000|
myeloid cell-specific leucine-rich glycoprotein, monocyte differentiation antigen CD14