Immunogen sequence: DVVVQAPTQV PGFLGDSVTL PCYLQVPNME VTHVSQLTWA RHGESGSMAV FHQTQGPSYS ESKRLEFVAA RLGAELRNAS LRMFGLRVED EGNYTCLFVT FP
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: CD155; HVED; NECL-5; NECL5; Nectin-like protein 5; Poliovirus receptor; PVS; Tage4
Gene Aliases: CD155; HVED; Necl-5; NECL5; PVR; PVS; TAGE4
UniProt ID: (Human) P15151
Entrez Gene ID: (Human) 5817