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Proteintech
CD157 Polyclonal Antibody
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Product Details
16337-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD157 Fusion Protein Ag9491 (40-318 aa encoded by BC012095)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SAHLRDIFL GRCAEYRALL SPEQRNKNCT AIWEAFKVAL DKDPCSVLPS DYDLFINLSR HSIPRDKSLF WENSHLLVNS FADNTRRFMP LSDVLYGRVA DFLSWCRQKN DSGLDYQSCP TSEDCENNPV DSFWKRASIQ YSKDSSGVIH VMLNGSEPTG AYPIKGFFAD YEIPNLQKEK ITRIEIWVMH EIGGPNVESC GEGSMKVLEK RLKDMGFQYS CINDYRPVKL LQCVDHSTHP DCALKSAAAA TQRKAPSLYT EQRAGLIIPL FLVLASRTQL (40-318 aa encoded by BC012095)
Target Information
CD157, also known as Bone Marrow Stromal Cell Antigen 1 (BST1), is a pleiotropic ectoenzyme and glycosylphosphatidylinositol-anchored molecule that functions both as an enzyme and a receptor. Similar to CD38, CD157 is involved in the metabolism of NAD+, which may play a role in regulating intracellular Ca2+ levels. As an enzyme, CD157 is also referred to as ADP-ribosyl cyclase 2 and DAMP-1, and it facilitates pre-B cell growth. As a receptor, CD157 is thought to initiate a signal transduction cascade upon binding to its putative ligand, leading to the phosphorylation of cytoplasmic proteins, including focal adhesion kinase (FAK). While the mechanism and functional significance of CD157-initiated signal transduction are not fully characterized, its role in cellular signaling is evident. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis, suggesting a link to polyclonal B cell abnormalities observed in the disease. This overexpression in the stromal cell population may contribute to the pathophysiology of rheumatoid arthritis, highlighting the importance of CD157/BST1 in both normal immune function and disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Antigen BP3; Bone marrow stromal antigen 1; Bone marrow stromal cell antigen 1; BP-3 alloantigen; BST-1; cADPR hydrolase 2; CD157; CD157 antigen; Cyclic ADP-ribose hydrolase 2; Leukocyte antigen 65; Ly-65; NAD(+) nucleosidase; NAD+ nucleosidase; unnamed protein product
Gene Aliases: 114/A10; A530073F09; BP-3; Bp3; BST1; Bsta1; cADPR2; CD157; Ly65
UniProt ID: (Human) Q10588, (Mouse) Q64277
Entrez Gene ID: (Human) 683, (Mouse) 12182
regulation of cell-matrix adhesion
regulation of cellular extravasation
humoral immune response
signal transduction
positive regulation of cell proliferation
positive regulation of B cell proliferation
regulation of actin cytoskeleton organization
regulation of inflammatory response
regulation of calcium-mediated signaling
regulation of neutrophil chemotaxis
regulation of superoxide metabolic process
regulation of integrin-mediated signaling pathway
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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