Search
Proteintech
CD177 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
18264-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD177 fusion protein Ag13146
Conjugate
Form
Liquid
Concentration
0.85 mg/mL
Amount
127.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: TVQHVWKVSD LPRQWTPKNT SCDSGLGCQD TLMLIESGPQ VSLVLSKGCT EAKDQEPRVT EHRMGPGLSL ISYTFVCRQE DFCNNLVNSL PLWAPQPPAD PGSLRCPVCL SMEGCLEGTT EEICPKGTTH CYDGLLRLRG GGIFSNLRVQ GCMPQPGCNL LNGTQEIGPV GMTENCNRKD FLTCHRGTTI MTHGNLAQEP TDWTTSNTEM CEVGQVCQET LLLLDVGLTS TLVGTKGCST VGAQNSQKTT IHSAPPGVLV ASYTHFCSSD LCNSASSSSV LLNSLPPQAA PVPGDRQCPT CVQPLGTCSS GSPRMTCPRG TTHCYDGYIH LSGGGLSTKM SIQGCVAQPS SFLLNHTRQI GIFSAREKRD VQPPASQHEG GGAEGLESL
Target Information
CD177 (NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly on neutrophils. Its plasma membrane expression is increased during pregnancy and and inflammation or after G-CSF application. Ligand of CD177 has been identified as CD31 (PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal alloimmune neutropenia (NAN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD177; CD177 antigen; cell surface receptor; HNA-2a; Human neutrophil alloantigen 2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; unnamed protein product
Gene Aliases: 1190003K14Rik; CD177; HNA-2a; HNA2A; NB1; NB1 GP; Pdp3; PRV-1; PRV1; UNQ595/PRO1181
UniProt ID: (Human) Q8N6Q3, (Mouse) Q8R2S8
Entrez Gene ID: (Human) 57126, (Mouse) 68891
biological_process
immune system process
cell adhesion
leukocyte cell-cell adhesion
regulation of endocytosis
positive regulation of superoxide anion generation
protein localization to cell surface
positive regulation of neutrophil degranulation
innate immune response
cell-cell junction maintenance
neutrophil extravasation
cell-cell adhesion via plasma-membrane adhesion molecules
neutrophil migration
regulation of integrin-mediated signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support