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Proteintech
CD2 Polyclonal Antibody
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Product Details
23973-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CD2 Fusion Protein Ag21122 (1-351 aa encoded by BC033583)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSFPCKFVA SFLLIFNVSS KGAVSKEITN ALETWGALGQ DINLDIPSFQ MSDDIDDIKW EKTSDKKKIA QFRKEKETFK EKDTYKLFKN GTLKIKHLKT DDQDIYKVSI YDTKGKNVLE KIFDLKIQER VSKPKISWTC INTTLTCEVM NGTDPELNLY QDGKHLKLSQ RVITHKWTTS LSAKFKCTAG NKVSKESSVE PVSCPEKGLD IYLIIGICGG GSLLMVFVAL LVFYITKRKK QRSRRNDEEL ETRAHRVATE ERGRKPQQIP ASTPQNPATS QHPPPPPGHR SQAPSHRPPP PGHRVQHQPQ KRPPAPSGTQ VHQQKGPPLP RPRVQPKPPH GAAENSLSPS SN (1-351 aa encoded by BC033583)
Target Information
CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD2; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
Gene Aliases: CD2; LFA-2; SRBC; T11
UniProt ID: (Human) P06729
Entrez Gene ID: (Human) 914
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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