|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to the C terminus of MS4A1, amino acids QDQESSPIENDSSP.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.03-0.1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Memory B-cell aggregates in skin biopsy are diagnostic for primary Sjögren's syndrome.
PA1-9024 was used in immunocytochemistry to investigate the use of B-cell skin infiltrates in the diagnosis of Sjogren's syndrome.
|Roguedas AM,Pers JO,Lemasson G,Devauchelle V,Tobón GJ,Saraux A,Misery L,Youinou P||Journal of autoimmunity (35:241)||2010|
BAFF-modulated repopulation of B lymphocytes in the blood and salivary glands of rituximab-treated patients with Sjögren's syndrome.
PA1-9024 was used in immunohistochemistry to investigate the mechanism for the repopulation of B lymphocytes after rituximab treatment
|Pers JO,Devauchelle V,Daridon C,Bendaoud B,Le Berre R,Bordron A,Hutin P,Renaudineau Y,Dueymes M,Loisel S,Berthou C,Saraux A,Youinou P||Arthritis and rheumatism (56:1464)||2007|
Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome.
PA1-9024 was used in immunohistochemistry to investigate the role of transitional type II B cells in the local production of autoantibodies and the destruction of epithelial cells
|Daridon C,Pers JO,Devauchelle V,Martins-Carvalho C,Hutin P,Pennec YL,Saraux A,Youinou P||Arthritis and rheumatism (54:2280)||2006|