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Invitrogen
CD200R Polyclonal Antibody
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FIGURE: 1 / 1
CD200R Antibody (PA5-86924) in WB
Western blot analysis of CD200R in Lane 1: L02 whole cell lysate (40 µg), Lane 2: A549 whole cell lysate (40 µg), Lane 3: AML-12 whole cell lysate (40 µg), Lane 4: H9C2 whole cell lysate (40 µg). Sample was incubated with CD200R polyclonal antibody (Product # PA5-86924) using a 1:1000 dilution.
Product Details
PA5-86924
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human CD200R1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
CD200R (OX2R) is a receptor for the OX-2 membrane glycoprotein, and both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. CD200R is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. In mouse, CD200R is expressed primarily by peripheral blood monocytes and neutophils but also by other leucocytes including T-lymphocytes and mast cells. Further mouse studies of a gene related to CD200R suggests that the receptor may control myeloid function in a tissue-specific manner. Alternative splicing of CD200R results in multiple transcript variants. Diseases associated with CD200R dysfunction include primary hypertrophic osteoarthropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen identified by monoclonal antibody MRC OX-2 receptor; CD200 cell surface glycoprotein receptor; CD200 R1; Cell surface glycoprotein CD200 receptor 1; Cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200; HuCD200R1; MOX2 receptor; Orexin receptor 2; OX102 antigen; OX2 receptor; unnamed protein product
Gene Aliases: CD200R; CD200R1; CRTR2; HCRTR2; MOX2R; OX2R; UNQ2522/PRO6015
UniProt ID: (Human) Q8TD46, (Mouse) Q9ES57, (Rat) Q9ES58
Entrez Gene ID: (Human) 131450, (Mouse) 57781, (Rat) 64357
signal transduction
negative regulation of interleukin-6 production
heterotypic cell-cell adhesion
intracellular signal transduction
Fc receptor signaling pathway
regulation of neuroinflammatory response
negative regulation of neuroinflammatory response
negative regulation of macrophage migration
negative regulation of T cell migration
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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