Invitrogen

CD202b (TIE2) Polyclonal Antibody

View all (56) TIE2 (TEK) antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
CD202b (TIE2) Polyclonal Antibody

Product Details

PA5-116042

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TEK(Accession Q02763), corresponding to amino acid residues E872-T922.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900676

Product Specific Information

Antibody detects endogenous levels of total TIE2.

Target Information

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; hTIE2; HYK; mTIE2; p140 TEK; STK1; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2

View more View less

Gene Aliases: AA517024; CD202B; Hyk; STK1; TEK; TIE-2; TIE2; VMCM; VMCM1

View more View less

UniProt ID: (Human) E7EWI2, (Mouse) Q02858

View more View less

Entrez Gene ID: (Human) 7010, (Mouse) 21687

View more View less

Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding growth factor binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
MAPK cascade angiogenesis response to hypoxia positive regulation of protein phosphorylation endothelial cell proliferation positive regulation of endothelial cell proliferation endochondral ossification sprouting angiogenesis signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cell-cell signaling heart development positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of angiogenesis peptidyl-tyrosine phosphorylation organ regeneration regulation of establishment or maintenance of cell polarity substrate adhesion-dependent cell spreading negative regulation of apoptotic process regulation of vascular permeability response to peptide hormone positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity response to estrogen positive regulation of angiogenesis protein autophosphorylation Tie signaling pathway negative regulation of inflammatory response leukocyte migration protein oligomerization response to cAMP positive regulation of focal adhesion assembly positive regulation of protein kinase B signaling definitive hemopoiesis heart trabecula formation positive regulation of ERK1 and ERK2 cascade positive regulation of intracellular signal transduction positive regulation of actin cytoskeleton reorganization regulation of endothelial cell apoptotic process negative regulation of endothelial cell apoptotic process patterning of blood vessels vasculogenesis regulation of endothelial cell proliferation positive regulation of cytokine secretion involved in immune response protein phosphorylation cell-matrix adhesion phosphorylation single organismal cell-cell adhesion hemopoiesis regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway response to retinoic acid positive regulation of peptidyl-serine phosphorylation intracellular signal transduction positive regulation of protein import into nucleus regulation of angiogenesis positive regulation of cell adhesion regulation of NIK/NF-kappaB signaling
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support