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Product Details
PA1-16825
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
2 µg/mL | - |
Immunocytochemistry (ICC/IF) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Non-human primate |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide made to an internal portion of the human MSR protein sequence (between residues 300-400). UniProt P21757 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.97 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
tris glycine with 150mM NaCl |
Contains |
0.05% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2298117 |
Product Specific Information
Suggested positive control: antigen standard for MSR1 (transient overexpression lysate), mouse liver lysate, mouse liver protein.
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; Scavenger receptor class A member 1; scavenger receptor class A, member 1; SR-AI/II
Gene Aliases: CD204; MSR1; phSR1; phSR2; SCARA1; SR-A; SRA
UniProt ID: (Human) P21757
Entrez Gene ID: (Human) 4481
Molecular Function:
serine protease
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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