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Product Details
PA5-95991
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:10 - 1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A recombinant fusion protein containing a sequence corresponding to amino acids 90-274 of human CD204. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.94 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.01% thimerosal |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2807793 |
Product Specific Information
Immunogen sequence: LNIENLNGKI QENTFKQQEE ISKLEERVYN VSAEIMAMKE EQVHLEQEIK GEVKVLNNIT NDLRLKDWEH SQTLRNITLI QGPPGPPGEK GDRGPTGESG PRGFPGPIGP PGLKGDRGAI GFPGSRGLPG YAGRPGNSGP KGQKGEKGSG NTLTPFTKVR LVGGSGPHEG RVEILHSGQW GTICDDRWEV RVGQVVCRSL GYPGVQAVHK AAHFGQGTGP IWLNEVFCFG RESSIEECKI RQWGTRACSH SEDAGVTCTL; Positive Samples: PC-3, HUVEC, U-937, 293T, Mouse liver, Mouse testis; Cellular Location: Membrane, Single-pass type II membrane protein
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; Scavenger receptor class A member 1; scavenger receptor class A, member 1; Scavenger receptor type A; SR-A; SR-AI/II
Gene Aliases: CD204; MRS-A; MSR; MSR-A; MSR1; phSR1; phSR2; RGD1564316; SCARA1; Scvr; SR-A; SR-AI; SR-AII; SRA
UniProt ID: (Human) P21757, (Mouse) P30204
Entrez Gene ID: (Human) 4481, (Rat) 498638, (Mouse) 20288
Molecular Function:
serine protease
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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