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Invitrogen
CD204 Polyclonal Antibody
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Product Details
PA5-95991
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.89 mg/mL
Amount
189 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ANDITQSLTG KGNDSEEEMR FQEVFMEHMS NMEKRIQHIL DMEANLMDTE HFQNFSMTTD QRFNDILLQL STLFSSVQGH GNAIDEISKS LISLNTTLLD LQLNIENLNG KIQENTFKQQ EEISKLEERV YNVSAEIMAM KEEQVHLEQE IKGEVKVLNN ITNDLRLKDW EHSQTLRNIT LIQGP
Positive Samples: PC-3, HUVEC, U-937, 293T, Mouse liver, Mouse testis; Cellular Location: Membrane, Single-pass type II membrane protein
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD204; Macrophage acetylated LDL receptor I and II; macrophage scavenger receptor type III; Macrophage scavenger receptor types I and II; Scavenger receptor class A member 1; Scavenger receptor type A; SR-A; SR-AI/II; unnamed protein product
Gene Aliases: CD204; MRS-A; MSR; MSR-A; MSR1; phSR1; phSR2; RGD1564316; SCARA1; Scvr; SR-A; SR-AI; SR-AII; SR-AIII; SRA
UniProt ID: (Human) P21757, (Mouse) P30204
Entrez Gene ID: (Human) 4481, (Rat) 498638, (Mouse) 20288
endocytosis
receptor-mediated endocytosis
phagocytosis, engulfment
negative regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol storage
cholesterol transport
plasma lipoprotein particle clearance
lipoprotein transport
establishment of localization in cell
beta-amyloid clearance
cellular response to organic cyclic compound
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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